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The historic confines of Wrigley Field will host an intriguing MLB matchup this Friday afternoon as the Chicago Cubs welcome the Philadelphia Phillies for a 2:20 PM ET contest on April 25, 2025.

On the mound, the Cubs will send Colin Rea to face the visitors. Rea enters the game with a pristine 0-0 record but has impressed with a stellar 1.32 ERA in his appearances this season. The Phillies counter with the experienced Taijuan Walker, who brings a 1-1 record and solid 2.29 ERA into the contest.

Advanced analytics give a slight edge to the home team. After running 10,000 simulations of Friday's game, predictive models indicate the Cubs have approximately a 54% probability of securing a victory, while Philadelphia sits at 46%.

"After computing the latest updates and thousands of other inputs, our simulations strongly suggest Chicago holds the advantage in this matchup," noted Nick Slade, Chief Content Officer at the analytics firm behind these projections.

The run line analysis shows Philadelphia at +1.5 with a 65% chance of covering, suggesting a potentially tight contest. Meanwhile, the over/under has been set at 8 runs, with models slightly favoring the over at 54% probability.

According to Statbet analysis, home field advantage at Wrigley Field has historically provided the Cubs with approximately a 5% performance boost in afternoon games, which aligns closely with the current prediction models for this matchup.

First pitch is scheduled for 2:20 PM Eastern Time (11:20 AM Pacific) at the iconic Wrigley Field. Baseball enthusiasts looking for a competitive midday contest should find plenty to enjoy as these two National League teams face off in what promises to be a closely contested affair.